[Right atrial thrombus: a rare presentation of plasminogen activator inhibitor deficiency].

Prothrombotic State in Patients With a Left Atrial Appendage Thrombus of Unknown Origin and Cerebrovascular Events.

BACKGROUND AND PURPOSE We hypothesized that formation of left atrial appendage (LAA) thrombi of unknown origin is associated with altered fibrin clot properties and blood hypercoagulability. METHODS In a case-control study, we investigated 32 patients with a history of LAA thrombus after successful anticoagulant treatment versus 32 control subjects matched for age, sex, and diabetes mellitus....

Accelerated thrombus lysis in the blood of plasminogen activator inhibitor deficient mice is inhibited by PAI-1 with a very long half-life.

Patients with defective plasminogen activator inhibitor protein (PAI-1) or with PAI-1 deficiency can experience hemorrhage as a result of a hyperfibrinolysis. In these patients, a normal thrombus forms, but endogenous lysis is unchecked as tissue plasminogen activator is unopposed. Treatment includes anti-fibrinolytic agents, including oral tranexamic acid. Another treatment option is the admin...

Sub-Massive Pulmonary Embolism with Large Intra-Cardiac Bi-Atrial Thrombi Successfully Treated with Systemic Thrombolytic Therapy

Herein we report a case of 46-year-old male patient who was presented with chest pain and dyspnea and was diagnosed with sub-massive pulmonary embolism (PE) and intra-cardiac bi-atrial thrombus, echocardiography showed decreased right ventricular systolic function. Following treatment with 100 mg tissue plasminogen activator (tPA), the patient reported clinical improvement, in addition to impro...

Methyltetrahydrofolate Reductase C677T Mutation and 4G/5G Plasminogen Activator Inhibitor-1 Polymorphism in a Child with Deep Vein Thrombosis

Role of endothelial dysfunction in thrombus formation in the left atrium-protective role of nitric oxide synthesis in the surface of atrium.

ent from that of the vascular wall, but the reduction of similar anticoagulation factors, including thrombomodulin, NO, and tissue plasminogen activator, or upregulation of plasminogen activator inhibitor-1, has been documented in the LA wall in the elderly in whom a hypercoagulation state can be speculated.4–6 Thus, endothelial dysfunction is probably involved, at least in part, in the mechani...